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Salmeterol is the first long acting selective β2 agonist with a slow onset of action; used by inhalation on a twice daily schedule for maintenance therapy and for occurring asthma, but not for acute symptoms. Salmeterol reduces breathlessness by preventing expiratory closure of peripheral airways and abolishing the reversible component of airway obstruction. Fluticasone is an Inhaled steroid it suppresses bronchial inflammation, increases peak expiratory flow rate, reduces the need for rescue β2-agonist inhalations, and prevents episodes of acute asthma.