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Ramipril The distinctive feature of this long-acting ACE(angiotensin-converting enzyme) inhibitor is its extensive tissue distribution. Greater inhibition of local RAS(Renin-angiotensin system) has been claimed.it is used in the treatment of hypertension, CHF, Myocardial Infection, etc. Chlorthalidone is thiazide and related diuretics used to treat hypertension and oedemas and renal calculi.